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Pittsburgh, PA
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Qian's Lab for MRI GLC#: L01-000-000-0001
Owner: Yongxian Qian, PhD.
BSc in Physics, 1982, Southwest Petroleum Institute (Nanchong, Sichuan, China)
PhD in Biomedical Engineering (MRI), 2002, Huazhong University of Science and Technology (Wuhan, Hubei, China);
2003 - 2006, Post-Doc Associate in MRI, University of Pittsburgh (Pittsburgh, PA, USA);
2006 - 2009, Research Instructor of Radiology, University of Pittsburgh (Pittsburgh, PA, USA);
2009 - 2014, Assistant Professor of Radiology, University of Pittsburgh (Pittsburgh, PA, USA);
2014 - present, Founder & CEO, General Labs Cloud LLC (Pittsburgh, PA, USA);
2000-present, Member of International Society of Magnetic Resonance in Medicine (ISMRM)
Email: qiany@glabscloud.com.
Mission: Our lab aims to develop innovative magnetic resonance imaging (MRI) techniques for clinical use. In particular, we focus on pulse sequence development, image reconstruction and data processing for diagnosis and treatment monitoring of diseases. Main focuses are (i) development of ultrashort echo time (UTE) techniques to assess early degeneration in cartilages in the knee at high risk of osteoarthritis (OA), (ii) development of sodium (23Na) MRI techniques to assess early response to cancer therapies for brain, breast and prostate cancers, and (iii) development of cellular-level MRI techniques to assess acute and chronic nerve cell injuries in neurological disorders such as concussion, epilepsy and others. We create an environment that encourages learning, testing and creating of new ideas and concepts.
Skills/Expertise/Experience
Skills:
1. Software development for MRI data processing with C/C++ and MATLAB.
2. Programming for MRI image reconstruction on Siemens ICE platform.
3. Programming for MRI pulse sequences on Siemens IDEA and GE EPIC.
Expertise:
1. T2/T2*/T1/T1rho mapping (mono- or bi-exponential fitting).
2. Spiral or non-Cartesian k-space data acquisiiton and image reconstruction.
3. Utrashort echo time (UTE) imaging, including high-resolution UTE imaging.
4. Quantitative sodium (23Na) imaging (total and bound/intracellular sodium).
Experience:
1. UTE/Sodium pulse sequence & image recon development on Siemens scanners at 3T and 7T and on GE scanners at 3T.
2. Clinical studies on early detection/treatment evaluation of osteoarthritis (OA) in the knee joint.
3. Clinical studies on quantitative evaluation of cancer cell response to treatment in the brain (via sodium 23Na imaging).
4. Clinical studies on evaluation of neurological disorders (bipolar and concussion) via proton 1H, sodium 23Na, and/or lithium 7Li imaging.Facilities/Products/Services
Facilities:
1. Access to Siemens MRI scanners at 3T, 7T and PET/MR.
2. 64-bit computers for data processing.
Products:
1. A MATLAB-based standalone software (pM1) for T2/T2*/T1rho mapping.2. A MATLAB-based standalone software (rbMC) for rigid-body motion correction.
3. A MATLAB-based standalone software (pM2) for bi-component T2/T2* mapping.
4. Bound (Intracellular) sodium quantification MRI technology.
5. High resolution ultrashort echo time (HR-UTE) MRI technology.
Services:
1. Data processing for T2/T2*/T1/T1rho mapping(mono-exponential curve fitting).
2. Data processing for T2/T2* mapping(bi-exponential curve fitting).
3. Consulting for UTE imaging, including pulse sequence and image recon.
4. Consulting for sodium (23Na) imaging, including sequence, recon, and quantification.
5. Data processing for quantification of total and bound/intracellular sodium concentratons.If you are interested in any products or services above, please contact the lab PI.
Collaborative Projects
On-going:
1. Brain Tumor: Intracellular sodium (23Na) MRI for noninvasive assessment of early response to cancer therapies for brain tumors (GBM).2. Knee OA: Short-component T2* mapping on cartilages for early assessment of osteoarthritis (OA) in the knee.
Pending:
1. Knee Cartilage: High-resolution UTE imaging for noninvasive ICRS-scale grading of cartilage damages in the knee. (In-plane resolution up to 0.14 mm)2. Concussion/mTBI: Sodium (23Na) and UTE MRI for detection of nerve cell injuries in concussed patients.
3. Breast/Prostate cancer: Intracellular sodium (23Na) MRI for noninvasive assessment of early response to cancer therapies for breast/prostate cancers.
If you are interested in any collaborations above, please contact the lab PI.
Research Projects
On-going:
1. Software development of bi-exponential T2/T2* mapping (MATLAB-based standalone deployment, completed on August 3, 2014).
2. Motion correction in T2/T2*/T1/T1rho mapping on the knee/heart/brain (Completed on July 31, 2014).
3. Multi-modality image data analysis of cancer cell response to treatment (PET-FLT/ML10, and MRI-23Na).
4. Quantitative sodium (23Na) MR imaging on pediatric patients with brain tumors (total and intracellular sodium).
Pending:
1. High-resolution UTE imaging on the knee.
2. Comprehensive MRI assessment of early degeneration in articular cartilages in the knee.
3. MRI evaluation of nerve cell injuries in concussion patients (high-resolution UTE imaging and intracellular sodium imaging).If you are interested in any research projects above, please contact the lab PI.
Pittsburgh, PA
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